Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases
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Transformation of Arachidonic Acid by Rabbit Polymorphonwclear Leukocytes
A new metabolite of arachidonic acid, 5-D-@),12-D(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid, was found upon incubation of the fatty acid with a suspension of rabbit peritoneal polymorphonuclear leukocytes collected 4 h after injection of glycogen into the peritoneal cavity. The yield of the dihydroxy acid was 0.5 to 2%. The compound possesses three conjugated double bonds and was found to be...
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Dietary gamma-linolenic acid (GLA), a omega-6 polyunsaturated fatty acid found in borage oil (BOR), lowers systolic blood pressure in spontaneously hypertensive rats (SHRs). GLA is converted into arachidonic acid (AA) by elongation and desaturation steps. Epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) are cytochrome P450 (P450)-derived AA eicosanoids with importa...
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Essential fatty acids (EFAs) can be defined by classic definition, which defines EFAs as the fatty acids that are required for proper functioning of cells, but the body cannot synthesize them and, therefore, must be supplied by diet. According to this definition, there are only two EFAs: linolenic acid (LA, C18:2, n-6) and alpha-linolenic acid (ALA, C18:3, n-3). The functional definition of EFA...
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85. Arnold, L. E., Kleykamp, D., Votolato, N. A., Taylor, W. A., Kontras, S. B., and Tobin, K. Gamma-linolenic acid for attention-deficit hyperactivity disorder: placebo-controlled comparison to D-amphetamine. Biol.Psychiatry 1-151989;25(2):222-228. View urgess, J. R. other disruptive behaviors. Lipids 2003;38(10):100786. Stevens, L., Zhang, W., Peck, L., Kuczek, T., Grevstad, N., Mahon, A., Ze...
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Whereas insulin does not stimulate hexose transport in polymorphonuclear leukocytes, we recently reported that C5a causes the leukocytes to take up 2-[(3)H]deoxyglucose. We now find that fMet-Leu-Phe, in a concentration-related manner with an EC(50) (concentration producing 50% of stimulatory activity) of 1.2 nM, causes a 5.5-fold stimulation of deoxyglucose uptake. Moreover, arachidonic acid (...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1976
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)57008-9